Endocrine Abstracts

Glucocorticoid hormones play a key role in glucose, fat and protein metabolism and dampen immune and inflammatory reactions. Synthetic equivalents are widely used as therapeutic drugs. Upon hormone binding, the glucocorticoid receptor (GR) detaches from a cytoplasmic multiprotein complex, translocates to the nucleus and regulates the transcription of target genes either directly or indirectly through interference with other transcription regulators.While...

Efficiency of glucocorticoid receptor (GR) signaling is modulated by a variety of co-activators, including the transcription intermediary factor 2 (TIF-2). Although TIF-2 has been shown to amplify GR signaling in different cellular models and contexts, its system-physiological relevance has not been comprehensively examined. The present work investigated the role of TIF-2 in GR-mediated regulation of hypothalamo-pituitary-adrenal (HPA) axis activity in mice. Experiments were d...